Cobas 6800 System Overview for Molecular Testing

The Cobas 6800 System, developed by Roche Diagnostics, is a high-throughput, fully automated molecular testing platform. Designed for large clinical laboratories, it offers speed, accuracy, and flexibility for real-time PCR testing.

This system has become essential in modern diagnosticssupporting tests for infectious diseases, viral load monitoring, and more. In this guide, well explore how the Cobas 6800 works and its key features, benefits, and applications.

What is the Cobas 6800 system?

The Cobas 6800 is an integrated system that automates the entire workflow for real-time PCR-based molecular diagnostics. It can perform:

• Sample preparation

• Nucleic acid extraction

• PCR amplification

• Real-time detection

All in one streamlined platform. This end-to-end automation helps reduce manual labor, increase efficiency, and ensure high-quality results.

Key Features of the Cobas 6800 System

1. High Throughput

• Can process up to 384 tests in an 8-hour shift

• Ideal for high-volume labs handling thousands of samples per day

• Supports continuous loading, allowing labs to keep running without stopping

2. Fully Automated Workflow

From sample loading to result reporting, the system automates:

• Sample decapping

• Nucleic acid isolation

• PCR setup

• Amplification and detection

This reduces human error and improves reproducibility.

3. Dual Target Detection

The Cobas 6800 can detect two genetic targets in the same reaction. This enhances diagnostic sensitivity and supports:

• Multiplex testing

• Reflex testing strategies

4. Broad Assay Menu

The system supports a growing menu of FDA-approved and CE-marked assays, including:

• HIV-1 and HIV-2

• Hepatitis B and C

• HPV

• SARS-CoV-2

• CMV and EBV

• CT/NG and other STIs

Roche also provides an open channel for laboratory-developed tests (LDTs).

5. High Precision & Accuracy

• Uses Roches proprietary reagents and PCR technology

• Built-in quality control at every step

• Consistent, repeatable results even with low-copy targets

How the Cobas 6800 Works

Heres a simplified look at how the system handles a sample from start to finish:

1. Sample Loading: Up to 94 samples are loaded at a time into racks.

2. Automated Preparation: The system prepares each sample, extracts nucleic acids, and sets up the PCR reaction.

3. Real-Time PCR Detection: Amplification and detection happen in a closed environment, reducing contamination risks.

4. Result Output: Results are sent directly to the labs LIS (Laboratory Information System).

Each step is monitored, ensuring full traceability and regulatory compliance.

Benefits of Using the Cobas 6800

Efficiency at Scale

With the ability to run hundreds of tests per shift, the Cobas 6800 maximizes lab output without increasing manual workload.

Improved Lab Productivity

Automated sample prep and detection help reduce human error, freeing staff for other critical tasks.

Faster Turnaround Times

Labs can deliver results within hours, even for large batchescritical during outbreaks or urgent clinical needs.

Lower Cost per Test

High-volume capacity, automated workflows, and efficient reagent use all contribute to reduced operating costs over time.

Future-Proof Platform

The Cobas 6800 supports expanded assay menus and LDTs, allowing labs to stay ahead of new diagnostic needs.

Ideal Applications of the Cobas 6800

The Cobas 6800 is used in:

• Large clinical laboratories

• Public health testing centers

• Reference labs

• Hospital labs with high sample volumes

It is particularly valuable in:

• Infectious disease diagnostics

• Epidemiological testing

• Viral load monitoring

• Routine STI and blood screening

Cobas 6800 vs. Other PCR Platforms

Final Thoughts

The Cobas 6800 System is a game-changer in molecular diagnostics. With its high throughput, full automation, and accurate real-time PCR testing, it enables labs to handle large volumes while maintaining the highest quality standards.

For labs aiming to improve speed, accuracy, and efficiency, the Cobas 6800 offers a complete, scalable solution thats ready for todays diagnostic challengesand tomorrows.